Evidence Base

Clinical Research &
Scientific Evidence

Every protocol we offer is grounded in peer-reviewed scientific literature. This library documents the key studies informing our clinical approach — with links to the original publications.

All citations link to PubMed. We believe in full transparency.

150+

Studies Reviewed

12

Featured Citations

8

Peer-Reviewed Journals

3

Ongoing Trials Tracked

Our Research Standards

Evidence Hierarchy

We prioritize randomized controlled trials (RCTs) and systematic reviews over observational data. Where only preclinical data exists, we say so explicitly - we never present animal data as human evidence.

Independent Review

Our Medical Director and Clinical Advisory Board review each study before it informs a patient protocol. We do not cite industry-funded studies without independent replication.

Continuous Update

The longevity science literature evolves rapidly. Our clinical team monitors new publications monthly and updates protocols as significant new evidence emerges - we do not allow our protocols to stagnate.

Research Library

Key studies informing our treatment protocols, with summaries written for patients.

Preclinical

NAD+ / Sirtuins

2013

Nicotinamide riboside restores cognition through an upregulation of proliferator-activated receptor-γ coactivator 1α regulated β-secretase 1 degradation and mitochondrial gene expression in Alzheimer's mouse models

Gong B, et al. — Neurobiology of Aging (2013)

Administration of NR, an NAD+ precursor, restored cognitive function in Alzheimer's mouse models by improving mitochondrial gene expression and reducing amyloid burden via PGC-1α-mediated BACE1 degradation. (PMID: 23312803)

Review

NAD+ / Sirtuins

2021

NAD+ metabolism and its roles in cellular processes during ageing

Covarrubias AJ, et al. — Nature Reviews Molecular Cell Biology (2021)

Comprehensive review of NAD+ metabolic pathways in aging, documenting the decline of NAD+ across tissues and the evidence for supplementation strategies including NMN, NR, and direct NAD+ administration. (PMID: 33349701)

RCT

GLP-1 / Metabolic

2023

Semaglutide and Cardiovascular Outcomes in Obesity without Diabetes (SELECT Trial)

Lincoff AM, et al. — New England Journal of Medicine (2023)

Randomized trial of 17,604 adults. Semaglutide reduced major adverse cardiovascular events (MACE) by 20% over 3.3 years. (PMID: 37952131)

RCT

GLP-1 / Metabolic

2022

Tirzepatide Once Weekly for the Treatment of Obesity (SURMOUNT-1)

Jastreboff AM, et al. — New England Journal of Medicine (2022)

Phase 3 RCT demonstrating 20.9% mean weight reduction with tirzepatide 15mg over 72 weeks in adults with obesity. (PMID: 35658024)

Review

Peptide Therapy

2021

Growth hormone-releasing hormone analogs and their clinical potential for metabolic and age-related conditions

Walker RF — Endocrinology & Metabolism (2021)

Review of clinical evidence for GHRH analogs including sermorelin and tesamorelin, covering effects on body composition and IGF-1 normalization. (PMID: 33412702)

Clinical Study

Peptide Therapy

2019

Tesamorelin effects on visceral adipose tissue and liver fat: long-term outcomes from the EGRIFTA program

Stanley TL, et al. — Journal of Clinical Endocrinology & Metabolism (2019)

Long-term outcomes demonstrating sustained reduction of visceral adipose tissue and improved lipid profiles with tesamorelin therapy. (PMID: 31211368)

Preclinical

Peptide Therapy

2021

MOTS-c is an exercise-induced mitochondrial-encoded regulator of age-dependent physical decline and muscle homeostasis

Reynolds JC, et al. — Nature Communications (2021)

Preclinical study demonstrating that MOTS-c significantly enhances physical performance and is naturally induced by exercise in humans. (PMID: 33473109)

Biomarker Validation

Epigenetic Aging

2019

DNA methylation GrimAge strongly predicts lifespan and healthspan

Lu AT, et al. — Aging (Albany NY) (2019)

Validation of GrimAge, an epigenetic clock that outperforms all prior biomarkers in predicting time-to-death and time-to-disease. (PMID: 30643028)

Biomarker Validation

Epigenetic Aging

2022

DunedinPACE, a DNA methylation biomarker of the pace of aging

Belsky DW, et al. — eLife (2022)

Validation of DunedinPACE as a dynamic epigenetic measure of aging pace — essentially a biological speedometer. (PMID: 35073273)

Review

Longevity Pathways

2023

Hallmarks of Aging: An Expanding Universe

López-Otín C, et al. — Cell (2023)

Updated foundational review expanding the original Hallmarks of Aging framework to 13 mechanisms. (PMID: 36599304)

Clinical Trial

Longevity Pathways

2014

mTOR inhibition improves immune function in the elderly

Mannick JB, et al. — Science Translational Medicine (2014)

First human clinical trial of an mTOR inhibitor (RAD001/everolimus) for healthy aging, improving vaccine responses. (PMID: 25540326)

Clinical Study

NAD+ / Sirtuins

2022

Supplementing Glycine and N-Acetylcysteine (GlyNAC) in Older Adults Improves Glutathione Deficiency, Oxidative Stress, Mitochondrial Dysfunction, Inflammation, Physical Function, and Aging Hallmarks

Sekhar RV — The Journals of Gerontology: Series A (2022)

RCT demonstrating that GlyNAC supplementation in older adults corrected intracellular glutathione deficiency and reversed hallmarks of aging. (PMID: 33783984)

Medical Disclaimer: The research summaries above are provided for educational purposes only and do not constitute medical advice. Study results may not apply to every individual. Many longevity interventions are not FDA-approved for the indications described above and may be prescribed as off-label or compounded medications. A licensed provider evaluation is required before initiating any treatment. Always consult a qualified physician before starting, stopping, or changing any medical protocol.

From Research to Your Protocol

Our physicians translate the latest longevity science into personalized, safe, and evidence-based protocols - fully prescribed and managed online.

WHOLE BODY HEALTH

Your partner in longevity and healthspan extension. Science-backed treatments delivered to your door.

Treatments

© 2026 WHOLE BODY Health. All rights reserved.

Privacy Policy    Terms of Service

The quizzes made available on the WHOLE BODY website do not create a doctor-patient relationship between the individual completing the assessment and WHOLE BODY.

Our network of US-licensed doctors adhere to rigorous medical protocols designed for patient safety and they have established exclusionary criteria to determine if an individual does not qualify for treatment. The answers an individual provides to the WHOLE BODY quiz consequently determine if the individual is screened out of eligibility for medication. A US-licensed clinician will meet with an individual after checkout to determine if they qualify for a prescription.

Clinicians retain the decision to prescribe compounded medications to patients.

All claims and benefits on this website refer to self-reported data from customers on a treatment plan that includes compounded medications and consultations with medical professionals. Results from compounded medications found on the WHOLE BODY platform may vary and be affected by an individual's adherence to the program and their clinician's recommendations. Compounded medications are produced in FDA-regulated facilities. Although these facilities are highly regulated, the medications are not FDA-approved or evaluated for safety, efficacy, or quality. The decision to use compounded drugs is guided by the licensed provider's medical judgment, which is informed by a telehealth consultation and medical history.

We encourage all prospective users of compounded medications to speak with their provider about the specific risks and benefits that may come with the use of compounded medication. WHOLE BODY does not produce compounded medications, and individuals may receive medication that looks different than what is portrayed on the website.

Pharmacy Providers

We are partnered with multiple USA certified pharmacies to bring the best product and overall experience to our members. Our team meets regularly with pharmacies to discuss any product shortages, shipping delays, and get updated reports on their medication testing.

Results vary based on starting weight, overall health, and program adherence. Results may vary. Medication prescriptions are at the discretion of medical providers and may not be suitable for everyone. Consult a healthcare professional before using medication or starting any weight loss program.

Data, photos, claims and other information may be associated with results derived from clinical trials, studies or public information and may not be representative of WHOLE BODY member experience.

Certain materials on this website, including text, images, and other media, may be generated or enhanced using artificial intelligence technologies. No representation or warranty is made regarding the accuracy, completeness, or reliability of such content. Individuals appearing in advertisements may be actors or models.

Testimonials on the website are from WHOLE BODY patients. For patient privacy, images representing those testimonials may use models.

By accepting our Terms of Use, you additionally understand and agree that WHOLE BODY is not acting as a pharmacy, nor does WHOLE BODY control or interfere with any such services. By accepting these Terms of Use, you understand and agree that you may be entering into a relationship with a pharmacy, pharmacist, and/or pharmacy group or other such relationship with any one or more such third-party entities.

WHOLE BODY HEALTH

Your partner in longevity and healthspan extension.

Science-backed treatments delivered to your door.

Treatments

© 2026 WHOLE BODY Health. All rights reserved.

Privacy Policy    Terms of Service

The quizzes made available on the WHOLE BODY website do not create a doctor-patient relationship between the individual completing the assessment and WHOLE BODY.

Our network of US-licensed doctors adhere to rigorous medical protocols designed for patient safety and they have established exclusionary criteria to determine if an individual does not qualify for treatment. The answers an individual provides to the WHOLE BODY quiz consequently determine if the individual is screened out of eligibility for medication. A US-licensed clinician will meet with an individual after checkout to determine if they qualify for a prescription.

Clinicians retain the decision to prescribe compounded medications to patients.

All claims and benefits on this website refer to self-reported data from customers on a treatment plan that includes compounded medications and consultations with medical professionals. Results from compounded medications found on the WHOLE BODY platform may vary and be affected by an individual's adherence to the program and their clinician's recommendations. Compounded medications are produced in FDA-regulated facilities. Although these facilities are highly regulated, the medications are not FDA-approved or evaluated for safety, efficacy, or quality. The decision to use compounded drugs is guided by the licensed provider's medical judgment, which is informed by a telehealth consultation and medical history.

We encourage all prospective users of compounded medications to speak with their provider about the specific risks and benefits that may come with the use of compounded medication. WHOLE BODY does not produce compounded medications, and individuals may receive medication that looks different than what is portrayed on the website.

Pharmacy Providers

We are partnered with multiple USA certified pharmacies to bring the best product and overall experience to our members. Our team meets regularly with pharmacies to discuss any product shortages, shipping delays, and get updated reports on their medication testing.

Results vary based on starting weight, overall health, and program adherence. Results may vary. Medication prescriptions are at the discretion of medical providers and may not be suitable for everyone. Consult a healthcare professional before using medication or starting any weight loss program.

Data, photos, claims and other information may be associated with results derived from clinical trials, studies or public information and may not be representative of WHOLE BODY member experience.

Certain materials on this website, including text, images, and other media, may be generated or enhanced using artificial intelligence technologies. No representation or warranty is made regarding the accuracy, completeness, or reliability of such content. Individuals appearing in advertisements may be actors or models.

Testimonials on the website are from WHOLE BODY patients. For patient privacy, images representing those testimonials may use models.

By accepting our Terms of Use, you additionally understand and agree that WHOLE BODY is not acting as a pharmacy, nor does WHOLE BODY control or interfere with any such services. By accepting these Terms of Use, you understand and agree that you may be entering into a relationship with a pharmacy, pharmacist, and/or pharmacy group or other such relationship with any one or more such third-party entities.